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a VCF into rule-based ACMG\/AMP variant calls with HPO phenotype matching, literature evidence and traceable clinical reports. EU-hosted.\"\u003e\n\u003cdiv class=\"hero\"\u003e\u003cdiv class=\"hero-grid\"\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"hero-head\"\u003e\n\u003cdiv class=\"logo-tile\"\u003e\u003cimg src=\"https:\/\/folklore.helena.bio\/images\/logos\/folklore-logo.svg\" alt=\"Folklore logo\" itemprop=\"image\" loading=\"lazy\"\u003e\u003c\/div\u003e\n\u003cdiv class=\"name-block\"\u003e\n\u003cspan class=\"eyebrow\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"m12 3-1.9 5.8a2 2 0 0 1-1.3 1.3L3 12l5.8 1.9a2 2 0 0 1 1.3 1.3L12 21l1.9-5.8a2 2 0 0 1 1.3-1.3L21 12l-5.8-1.9a2 2 0 0 1-1.3-1.3Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Academic Research · Agents Orchestration Frameworks\u003c\/span\u003e\u003ch1 class=\"title\" itemprop=\"name\"\u003eFolklore\u003c\/h1\u003e\n\u003cp class=\"lede justify\" itemprop=\"description\"\u003eClinical genomics software that classifies germline variants from a VCF under the \u003cb\u003eACMG\/AMP\u003c\/b\u003e rules, adds HPO phenotype matching, literature evidence and prioritisation, then hands a traceable case record to a qualified geneticist for review and sign-off.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"badge-row\"\u003e\n\u003cspan class=\"badge ok\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003ccircle cx=\"12\" cy=\"12\" r=\"10\"\u003e\u003c\/circle\u003e\u003cpath d=\"m9 12 2 2 4-4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Active\u003c\/span\u003e\u003cspan class=\"badge ok\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M12 22s8-4 8-10V5l-8-3-8 3v7c0 6 8 10 8 10z\"\u003e\u003c\/path\u003e\u003cpath d=\"m9 12 2 2 4-4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e GDPR compliant\u003c\/span\u003e\u003cspan class=\"badge brand\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 12 20 22 4 22 4 12\"\u003e\u003c\/polyline\u003e\u003crect x=\"2\" y=\"7\" width=\"20\" height=\"5\"\u003e\u003c\/rect\u003e\u003cline x1=\"12\" y1=\"22\" x2=\"12\" y2=\"7\"\u003e\u003c\/line\u003e\u003cpath d=\"M12 7H7.5a2.5 2.5 0 0 1 0-5C11 2 12 7 12 7z\"\u003e\u003c\/path\u003e\u003cpath d=\"M12 7h4.5a2.5 2.5 0 0 0 0-5C13 2 12 7 12 7z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Free plan\u003c\/span\u003e\u003cspan class=\"badge\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"22 7 13.5 15.5 8.5 10.5 2 17\"\u003e\u003c\/polyline\u003e\u003cpolyline points=\"16 7 22 7 22 13\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e Freemium\u003c\/span\u003e\u003cspan class=\"badge\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e API available\u003c\/span\u003e\u003cspan class=\"badge\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M16 21v-2a4 4 0 0 0-4-4H6a4 4 0 0 0-4 4v2\"\u003e\u003c\/path\u003e\u003ccircle cx=\"9\" cy=\"7\" r=\"4\"\u003e\u003c\/circle\u003e\u003cpolyline points=\"16 11 18 13 22 9\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e 18+\u003c\/span\u003e\u003cspan class=\"badge brand\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003ccircle cx=\"12\" cy=\"12\" r=\"10\"\u003e\u003c\/circle\u003e\u003cpath d=\"m9 12 2 2 4-4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Verified by Guidaio\u003c\/span\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"tbd-row\"\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"label\"\u003eCategories\u003c\/div\u003e\n\u003cdiv class=\"chip-row\"\u003e\n\u003ca class=\"chip cat\" href=\"\/collections\/academic-research\"\u003eAcademic Research\u003c\/a\u003e\u003ca class=\"chip cat\" href=\"\/collections\/agents-orchestration-frameworks\"\u003eAgents Orchestration Frameworks\u003c\/a\u003e\u003ca class=\"chip cat\" href=\"\/collections\/api-tools\"\u003eApi Tools\u003c\/a\u003e\u003ca class=\"chip cat\" href=\"\/collections\/rag-semantic-search\"\u003eRag Semantic Search\u003c\/a\u003e\u003ca class=\"chip cat\" href=\"\/collections\/report-generation\"\u003eReport Generation\u003c\/a\u003e\u003ca class=\"chip cat\" href=\"\/collections\/workflow-automation\"\u003eWorkflow Automation\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"label\"\u003eTarget domains\u003c\/div\u003e\n\u003cdiv class=\"chip-row\"\u003e\n\u003ca class=\"chip dom\" href=\"\/collections\/healthcare-medicine\"\u003eHealthcare Medicine\u003c\/a\u003e\u003ca class=\"chip dom\" href=\"\/collections\/biotech-pharma\"\u003eBiotech Pharma\u003c\/a\u003e\u003ca class=\"chip dom\" href=\"\/collections\/science-r-d\"\u003eScience R D\u003c\/a\u003e\u003ca class=\"chip dom\" href=\"\/collections\/education-academia\"\u003eEducation 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fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolygon points=\"6 3 20 12 6 21 6 3\"\u003e\u003c\/polygon\u003e\u003c\/svg\u003e Read the documentation\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003caside class=\"snapshot\"\u003e\u003ch3\u003eSnapshot\u003c\/h3\u003e\n\u003cdl\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdt\u003ePricing model\u003c\/dt\u003e\n\u003cdd\u003eFreemium\u003c\/dd\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdt\u003eFree plan\u003c\/dt\u003e\n\u003cdd\u003eYes\u003c\/dd\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdt\u003eAPI available\u003c\/dt\u003e\n\u003cdd\u003eYes\u003c\/dd\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdt\u003eDeployment\u003c\/dt\u003e\n\u003cdd\u003eWeb app · API\u003c\/dd\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdt\u003eLanguages\u003c\/dt\u003e\n\u003cdd\u003eEnglish\u003c\/dd\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdt\u003eTool status\u003c\/dt\u003e\n\u003cdd\u003eActive\u003c\/dd\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdt\u003eMinimum age\u003c\/dt\u003e\n\u003cdd\u003e18+\u003c\/dd\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"row\"\u003e\n\u003cdt\u003eCountry of origin\u003c\/dt\u003e\n\u003cdd\u003e🇧🇬 Bulgaria\u003c\/dd\u003e\n\u003c\/div\u003e\n\u003c\/dl\u003e\u003c\/aside\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003cnav class=\"toc\" aria-label=\"Page sections\"\u003e\u003ca href=\"#what\"\u003eWhat is it\u003c\/a\u003e\u003ca href=\"#bestnot\"\u003eWhen to use Folklore \/ When not to\u003c\/a\u003e\u003ca href=\"#how\"\u003eHow to use\u003c\/a\u003e\u003ca href=\"#proscons\"\u003ePros \u0026amp; Cons\u003c\/a\u003e\u003ca href=\"#pricing\"\u003ePricing\u003c\/a\u003e\u003ca href=\"#trust\"\u003eTrust \u0026amp; Privacy\u003c\/a\u003e\u003ca href=\"#watch\"\u003eWatch-outs\u003c\/a\u003e\u003ca href=\"#setup\"\u003eSetup \u0026amp; Integrations\u003c\/a\u003e\u003ca href=\"#company\"\u003eCompany\u003c\/a\u003e\u003ca href=\"#resources\"\u003eResources\u003c\/a\u003e\u003ca href=\"#faq\"\u003eFAQ\u003c\/a\u003e\u003ca href=\"#conclusion\"\u003eConclusion\u003c\/a\u003e\u003c\/nav\u003e\n\u003csection class=\"block\" id=\"what\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eOverview\u003c\/span\u003e\u003ch2\u003eWhat is Folklore?\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"grid-2\"\u003e\n\u003cdiv class=\"rich justify\"\u003e\n\u003cp\u003e\u003cb\u003eFolklore\u003c\/b\u003e is clinical genomics software from Helena Bioinformatics, a Bulgarian company based in Sofia. It takes a single-sample VCF 4.1 or 4.2 file from a gene panel, exome or whole genome and turns it into a reviewable case record: annotated variants, an ACMG\/AMP classification with every applied criterion exposed, phenotype-ranked genes, scored literature and a report a qualified specialist signs.\u003c\/p\u003e\n\u003cp\u003eThe pipeline runs in six stages. Variants are quality-filtered, with clinically significant ClinVar entries preserved regardless of score. Annotation goes through Ensembl VEP release 113 from a local offline cache, joined to locally stored reference data including gnomAD v4.1, ClinVar, dbNSFP, HPO, ClinGen and precomputed SpliceAI. The vendor is precise about scale here: \u003cb\u003e16 production databases\u003c\/b\u003e sit in the core enrichment stage, while \u003cb\u003e45 reference databases and curated sources\u003c\/b\u003e is the total across every module. Classification then applies the 2015 ACMG\/AMP guidelines with all 28 evidence criteria in a Bayesian point framework. Folklore states plainly that classification is \u003ci\u003estrictly rule-based and that no AI model determines pathogenicity\u003c\/i\u003e; material relating to a version 4 of the standard is described as beta or draft, and no conformance with a final version 4 is claimed. PP3 and BP4 rest on BayesDel_noAF with ClinGen SVI-calibrated thresholds, with a separate guarded SpliceAI path. Scores such as SIFT, AlphaMissense, MetaSVM, DANN, PhyloP and GERP are displayed for clinical context and carry no ACMG vote of their own.\u003c\/p\u003e\n\u003cp\u003eAround that core sit modules for mitochondrial DNA under MMDWG 2020, structural and copy-number variants under Riggs 2020, family and trio inheritance analysis, cohort analytics, phenotype matching and clinical screening. Phenotype matching orders candidates by HPO semantic similarity; it does not rewrite a classification and neither score establishes a diagnosis. An AI assistant answers questions about the case and shows the SQL it generates, but cannot alter a classification.\u003c\/p\u003e\n\u003cp\u003ePrivate genomic processing runs on dedicated hardware in Helsinki, Finland, with no outbound network access from the analysis pipeline. Alongside the paid platform, Folklore publishes a free read-only MCP endpoint that classifies one public GRCh38 variant without any account. The vendor states the product is Research Use Only and not CE-marked.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003ch3 style=\"font-size:14px;margin-bottom:12px;color:var(--gv3-brand-ink);text-transform:uppercase;letter-spacing:.08em\"\u003eWhat it does\u003c\/h3\u003e\n\u003cul class=\"brand-list\"\u003e\n\u003cli\u003eClassify germline variants from a VCF under the ACMG\/AMP rules, with every applied criterion listed\u003c\/li\u003e\n\u003cli\u003eRank genes and variants against the patient's HPO phenotype profile using semantic similarity\u003c\/li\u003e\n\u003cli\u003eRetrieve and score biomedical literature with traceable PMID, DOI and extracted context\u003c\/li\u003e\n\u003cli\u003ePrioritise findings into clinical tiers using age, sex, ancestry, family history and testing indication\u003c\/li\u003e\n\u003cli\u003eInterpret mitochondrial variants under MMDWG and copy-number changes under the ClinGen\/ACMG Riggs framework\u003c\/li\u003e\n\u003cli\u003eGenerate a tiered clinical interpretation report in PDF or DOCX with full evidence attribution\u003c\/li\u003e\n\u003cli\u003eQuery one public GRCh38 variant for free through a read-only MCP endpoint, with no account or API key\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block soft\" id=\"bestnot\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eAudience\u003c\/span\u003e\u003ch2\u003eWhen to use Folklore \/ When not to\u003c\/h2\u003e\n\u003cp class=\"lead\"\u003eA quick filter to help you decide if Folklore is the right fit.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"bestnot\"\u003e\n\u003cdiv class=\"card for\"\u003e\n\u003ch3\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"16\" height=\"16\"\u003e\u003cpath d=\"M7 10v12\"\u003e\u003c\/path\u003e\u003cpath d=\"M15 5.88 14 10h5.83a2 2 0 0 1 1.92 2.56l-2.33 8A2 2 0 0 1 17.5 22H4a2 2 0 0 1-2-2v-8a2 2 0 0 1 2-2h2.76a2 2 0 0 0 1.79-1.11L12 2a3.13 3.13 0 0 1 3 3.88Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e When to use Folklore\u003c\/h3\u003e\n\u003cul class=\"brand-list\"\u003e\n\u003cli\u003eClinical genetics laboratories running roughly 50 to 500 inherited-disease exome or genome cases a year\u003c\/li\u003e\n\u003cli\u003eClinical geneticists who want evidence gathered, cross-referenced and documented before their own review begins\u003c\/li\u003e\n\u003cli\u003eRare-disease, newborn-screening and carrier-screening teams needing phenotype-aware prioritisation\u003c\/li\u003e\n\u003cli\u003eBioinformaticians and research groups analysing trios, families or whole cohorts under a locked classifier version\u003c\/li\u003e\n\u003cli\u003eDevelopers and AI agents that need a free, read-only variant-classification endpoint with no account or API key\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"card not\"\u003e\n\u003ch3\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"16\" height=\"16\"\u003e\u003cpath d=\"M17 14V2\"\u003e\u003c\/path\u003e\u003cpath d=\"M9 18.12 10 14H4.17a2 2 0 0 1-1.92-2.56l2.33-8A2 2 0 0 1 6.5 2H20a2 2 0 0 1 2 2v8a2 2 0 0 1-2 2h-2.76a2 2 0 0 0-1.79 1.11L12 22a3.13 3.13 0 0 1-3-3.88Z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e When not to use Folklore\u003c\/h3\u003e\n\u003cul class=\"brand-list\"\u003e\n\u003cli\u003ePatients or members of the public: the service is explicitly not offered directly to patients for diagnosis or treatment decisions\u003c\/li\u003e\n\u003cli\u003eSomatic and tumour work: tumour-normal analysis and AMP\/ASCO\/CAP classification are outside the product scope\u003c\/li\u003e\n\u003cli\u003eLaboratories needing repeat-expansion disorders, which are neither detected nor interpreted\u003c\/li\u003e\n\u003cli\u003eTeams looking for upstream variant or structural-variant calling: Folklore interprets a VCF, it does not produce one\u003c\/li\u003e\n\u003cli\u003eAny workflow requiring a CE-marked in vitro diagnostic device, since the vendor states the product is Research Use Only\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block soft\" id=\"how\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eGet started\u003c\/span\u003e\u003ch2\u003eHow to use Folklore\u003c\/h2\u003e\n\u003cp class=\"lead\"\u003eA typical end-to-end flow, from setup to results.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003col class=\"steps\"\u003e\n\u003cli\u003eTry the product first for free: search a single GRCh38 variant on the home page by coordinate, HGVS, SPDI or rsID\u003c\/li\u003e\n\u003cli\u003eOr connect an AI client to the public MCP endpoint over Streamable HTTP, with no account, API key or OAuth flow\u003c\/li\u003e\n\u003cli\u003eFor laboratory use, create an account and pick an Individual, Laboratory or Distributor profile\u003c\/li\u003e\n\u003cli\u003eExpect Helena to ask for evidence of professional qualification or organisational identity before clinical features are enabled\u003c\/li\u003e\n\u003cli\u003eHave an authorised representative accept or sign the data processing agreement before any patient data is submitted\u003c\/li\u003e\n\u003cli\u003eUpload a pseudonymised single-sample VCF 4.1 or 4.2 file, splitting multi-sample files beforehand\u003c\/li\u003e\n\u003cli\u003eSet the quality filters for read depth, genotype quality and allelic balance\u003c\/li\u003e\n\u003cli\u003eEnter the patient's HPO terms directly, by HP:ID, or by AI-assisted extraction from a referral letter\u003c\/li\u003e\n\u003cli\u003eChoose a built-in or custom gene panel and one of the six screening modes, then run the analysis\u003c\/li\u003e\n\u003cli\u003eReview the fired criteria and evidence, reclassify where your judgement differs, and generate the signed report\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/section\u003e\n\u003csection class=\"block\" id=\"proscons\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eQuick read\u003c\/span\u003e\u003ch2\u003ePros \u0026amp; Cons\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"grid-2\"\u003e\n\u003cdiv class=\"pc pros\"\u003e\n\u003ch3\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003ccircle cx=\"12\" cy=\"12\" r=\"10\"\u003e\u003c\/circle\u003e\u003cpath d=\"m9 12 2 2 4-4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Pros\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e \u003cspan\u003eClassification is deterministic and auditable: each result carries its criteria, its sources and the classifier version\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e \u003cspan\u003eNo AI model sits inside the class calculation, and the vendor separates generated text from the decision explicitly\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e \u003cspan\u003ePrivate genomic processing runs on dedicated EU hardware in Helsinki, outside multi-tenant cloud and outside claimed US jurisdiction\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e \u003cspan\u003eThe variant pipeline has no outbound network route by design, enforced at firewall and container level rather than in the application\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e \u003cspan\u003ePublic documentation is exceptionally dense, with 131 canonical pages, a per-version changelog and an explicit limitations page\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e \u003cspan\u003eValidation is published and citable: four cohorts covering 197 retrospective cases, with public reports carrying OSF DOIs\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e \u003cspan\u003eA free read-only machine interface needs no account or API key, and the adapter is open source under Apache-2.0\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"pc cons\"\u003e\n\u003ch3\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"16\" height=\"16\"\u003e\u003ccircle cx=\"12\" cy=\"12\" r=\"10\"\u003e\u003c\/circle\u003e\u003cline x1=\"4.93\" y1=\"4.93\" x2=\"19.07\" y2=\"19.07\"\u003e\u003c\/line\u003e\u003c\/svg\u003e Cons\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" y2=\"18\"\u003e\u003c\/line\u003e\u003cline x1=\"6\" y1=\"6\" x2=\"18\" y2=\"18\"\u003e\u003c\/line\u003e\u003c\/svg\u003e \u003cspan\u003eNo price is published anywhere: neither the product site nor the company site exposes a pricing page or any amount\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" y2=\"18\"\u003e\u003c\/line\u003e\u003cline x1=\"6\" y1=\"6\" x2=\"18\" y2=\"18\"\u003e\u003c\/line\u003e\u003c\/svg\u003e \u003cspan\u003eThe vendor states the product is Research Use Only and not CE-marked, so it cannot serve as an in vitro diagnostic device\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" y2=\"18\"\u003e\u003c\/line\u003e\u003cline x1=\"6\" y1=\"6\" x2=\"18\" y2=\"18\"\u003e\u003c\/line\u003e\u003c\/svg\u003e \u003cspan\u003eHelena holds no certification of its own; the ISO 27001 cited in the impact assessment belongs to Hetzner, its hosting subprocessor\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" y2=\"18\"\u003e\u003c\/line\u003e\u003cline x1=\"6\" y1=\"6\" x2=\"18\" y2=\"18\"\u003e\u003c\/line\u003e\u003c\/svg\u003e \u003cspan\u003eThe published cohort 4 result is 67.0% full plus clinical agreement over 100 cases, on the vendor's own figures\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" y2=\"18\"\u003e\u003c\/line\u003e\u003cline x1=\"6\" y1=\"6\" x2=\"18\" y2=\"18\"\u003e\u003c\/line\u003e\u003c\/svg\u003e \u003cspan\u003eAll three legal documents carry a \u003ci\u003eCandidate for legal review\u003c\/i\u003e banner, so the vendor itself flags them as unvalidated\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" y2=\"18\"\u003e\u003c\/line\u003e\u003cline x1=\"6\" y1=\"6\" x2=\"18\" y2=\"18\"\u003e\u003c\/line\u003e\u003c\/svg\u003e \u003cspan\u003eThe documentation contradicts itself on whether the clinical AI assistant may call an external language model API\u003c\/span\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"18\" y1=\"6\" x2=\"6\" y2=\"18\"\u003e\u003c\/line\u003e\u003cline x1=\"6\" y1=\"6\" x2=\"18\" y2=\"18\"\u003e\u003c\/line\u003e\u003c\/svg\u003e \u003cspan\u003eScope is strictly germline: no somatic variants, no repeat expansions, no upstream variant or structural-variant calling\u003c\/span\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block soft\" id=\"pricing\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003ePricing\u003c\/span\u003e\u003ch2\u003ePricing \u0026amp; Plans\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cp class=\"rich justify\" style=\"color:var(--gv3-ink-2);margin:0 0 18px;max-width:80ch\"\u003eA permanent free plan exists. The terms of use state that version 1.0 supports a free plan without a payment card, and that paid charges, taxes, renewal, cancellation and refund terms apply only if a paid offer is separately selected, with its ordering and billing terms presented before purchase. The public variant search and the read-only MCP endpoint are free and require no account. \u003cb\u003eNo paid price is published.\u003c\/b\u003e Neither the product site nor the company site exposes a pricing page, and no amount in any currency appears in the vendor's own complete public text corpus. To investors, Helena describes the commercial model as B2B software with usage-based and volume access, and a route running from an own-data pilot to per-case purchase, prepaid volume packs and then an annual commitment or private instance. Pricing enquiries are directed to the company's general contact address.\u003c\/p\u003e\n\u003cdiv class=\"pricing-extras\"\u003e\u003cdiv class=\"affiliate-note\"\u003ePrices and plans listed above may evolve. Always check the official pricing page before subscribing.\u003c\/div\u003e\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block\" id=\"trust\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eTrust \u0026amp; Privacy\u003c\/span\u003e\u003ch2\u003eData, GDPR \u0026amp; hosting\u003c\/h2\u003e\n\u003cp class=\"lead\"\u003eA consolidated view of how Folklore handles your data.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"trust-grid\"\u003e\n\u003cdiv class=\"col\"\u003e\n\u003cdiv class=\"trust-card\"\u003e\n\u003ch3\u003eGDPR overview\u003c\/h3\u003e\n\u003cp class=\"justify\" style=\"color:var(--gv3-ink-2);margin:0\"\u003eGDPR treatment is documented in unusual detail. A privacy notice, terms of use and data processing agreement are published in full, all version 1.0 effective 14 August 2026, alongside a public impact assessment summary (version 1.1, March 2026) carried out under Article 35 because genetic data is Article 9 special-category data. The laboratory is controller and chooses the Article 9(2)(a) or 9(2)(h) basis; Helena is processor. Private genomic processing stays inside the EEA, with standard contractual clauses reserved for any future transfer. Annex 3 of the agreement authorises a single subprocessor, Hetzner, for private customer data. The Bulgarian supervisory authority is named, and privacy@helena.bio is given as the data-protection contact, with an explicit caveat that this is not a formal DPO designation. All three legal documents carry a \u003cb\u003eCandidate for legal review\u003c\/b\u003e banner.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"trust-card\"\u003e\n\u003ch3\u003eWho owns the data?\u003c\/h3\u003e\n\u003cp class=\"justify\" style=\"color:var(--gv3-ink-2);margin:0 0 12px\"\u003eThe customer keeps ownership. The terms state that you retain your rights in the data, files and materials you submit, and grant Helena Bioinformatics only the limited rights needed to host, copy, transmit, analyse and process that content in order to provide, secure, support and maintain the service and to meet legal obligations. For genomic case data the laboratory is the data controller and Helena acts strictly as processor on documented instructions; Helena is controller only for account, security, contact and billing records. Patient data must be pseudonymised before upload. At the end of the agreement the controller chooses return or deletion. Separately, Helena claims a perpetual right over feedback you volunteer, without identifying you or disclosing customer data.\u003c\/p\u003e\n\u003ch3\u003eReuse rights\u003c\/h3\u003e\n\u003cp class=\"justify\" style=\"color:var(--gv3-ink-2);margin:0\"\u003eCustomer data is processed only on the controller's documented instructions, for delivering, securing, supporting and maintaining the service. Results belong to the laboratory and may be used in its own professional or research workflow, subject to third-party database licences, attribution requirements and patient rights, and no permission request to the vendor is described for that reuse. Two secondary uses are disclosed and deserve attention. The impact assessment states that de-identified data may be processed for internal research and development, algorithm validation and platform improvement under a separate data use agreement, with Helena then acting as an independent controller on a legitimate-interest basis. And the privacy notice names OpenAI as processing bounded content from the public assistant, with provider storage disabled in Helena's configured request. Nothing on the site states either that customer data trains AI models or that it does not; the classifier itself is rule-based, not trained. No documented mechanism lets a customer opt out of the research and development use.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"trust-card\"\u003e\n\u003ch3\u003eData retention \u0026amp; training\u003c\/h3\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eRetention summary\u003c\/div\u003e\n\u003cdiv class=\"v justify\"\u003eOriginal VCF files are deleted automatically once processing completes, and raw sequencing data is never accepted. Parsed variant data and the structured results, including ACMG evidence, phenotype scores, screening tiers and literature, are kept for the period agreed with the laboratory so that a case can be revisited without re-upload, and are removed when the session is deleted or the agreement ends. Phenotype and clinical context go with the session. Account details are deleted within 30 days of termination or on request, and IP addresses and session logs are purged after at most 12 months. Deletion on request is completed within 30 days and certified in writing, and every deletion event is logged. Processing metadata is kept for the audit trail and holds no genomic data. The impact assessment separately mentions a 90-day default retention period.\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eTrains on customer data\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e\u003cspan class=\"badge warn\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M12 22s8-4 8-10V5l-8-3-8 3v7c0 6 8 10 8 10z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Unclear\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eSubprocessors disclosed\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e\u003cspan class=\"badge ok\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolyline points=\"20 6 9 17 4 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e Yes\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eDPA available\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e\u003cspan class=\"badge ok\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M14 2H6a2 2 0 0 0-2 2v16a2 2 0 0 0 2 2h12a2 2 0 0 0 2-2V8z\"\u003e\u003c\/path\u003e\u003cpolyline points=\"14 2 14 8 20 8\"\u003e\u003c\/polyline\u003e\u003cpath d=\"m9 15 2 2 4-4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Yes\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eGDPR contact\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e\u003ca href=\"mailto:privacy@helena.bio\"\u003eprivacy@helena.bio\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"col\"\u003e\u003cdiv class=\"trust-card\"\u003e\n\u003ch3\u003eHosting summary\u003c\/h3\u003e\n\u003cp class=\"justify\" style=\"color:var(--gv3-ink-2);margin:0 0 14px\"\u003ePrivate genomic processing and storage run on dedicated hardware physically located in Helsinki, Finland, identified as a Hetzner server, rather than on multi-tenant cloud infrastructure. The vendor gives four reasons: physical isolation from other customers, a fixed and verifiable data location, no exposure to US disclosure laws because the hosting provider is a European company, and exclusive root-level access for Helena so that no hosting employee reaches the operating system, storage or network. Annex 3 of the data processing agreement authorises Hetzner alone to receive private customer data, and no public website, analytics, email, payment or public-AI provider is authorised for it. Data travels over TLS 1.3, and no genomic or personal data is transferred outside the European Economic Area; standard contractual clauses are reserved for any future transfer. Vercel serves the public websites and front ends and may see network and usage metadata, but not private genomic content. Note one documented inconsistency: encryption at rest is given as AES-256 on the infrastructure page and as AES-128 at application level plus full-disk encryption in the impact assessment.\u003c\/p\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eHosting countries\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e\u003cdiv class=\"flag-row\"\u003e\u003cspan class=\"flag\"\u003e🇫🇮 Finland\u003c\/span\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eHosting regions\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e\u003cdiv class=\"flag-row\"\u003e\u003cspan class=\"flag\"\u003eEU\u003c\/span\u003e\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block watch\" id=\"watch\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eWatch-outs\u003c\/span\u003e\u003ch2\u003eThings to keep in mind\u003c\/h2\u003e\n\u003cp class=\"lead\"\u003eRisks and trade-offs to weigh before adopting Folklore.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cul class=\"brand-list\" style=\"grid-template-columns:repeat(2,1fr);display:grid;gap:12px 24px\"\u003e\n\u003cli\u003eResearch Use Only and not CE-marked: do not deploy it as an in vitro diagnostic device or as the basis of a regulated report\u003c\/li\u003e\n\u003cli\u003eThe only certification named on the site, ISO 27001, is held by the hosting subprocessor Hetzner and must not be read as Helena's own\u003c\/li\u003e\n\u003cli\u003eThe documentation contradicts itself on external AI: the impact assessment and FAQ say all inference is local, while the no-external-calls page says the clinical assistant may use an external language model API\u003c\/li\u003e\n\u003cli\u003eRetention is stated twice and differently: a 90-day default in the impact assessment, a duration agreed with the laboratory on the retention page\u003c\/li\u003e\n\u003cli\u003eAutomation bias is the real clinical risk: the vendor insists the geneticist decides, and a 67.0% agreement rate on its largest cohort shows why that insistence matters\u003c\/li\u003e\n\u003cli\u003eThe public MCP endpoint accepts public variant data only; sending patient identifiers, phenotype or case context to it would be a disclosure incident\u003c\/li\u003e\n\u003cli\u003eDisplayed predictor scores such as SIFT, AlphaMissense, PhyloP and GERP are context only and carry no ACMG vote, so do not read them as criteria\u003c\/li\u003e\n\u003c\/ul\u003e\u003c\/section\u003e\n\u003csection class=\"block\" id=\"setup\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eSetup\u003c\/span\u003e\u003ch2\u003eSetup \u0026amp; Integrations\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"setup-grid\"\u003e\n\u003cdiv class=\"setup-card\"\u003e\n\u003ch3 style=\"font-size:15px;margin-bottom:10px\"\u003eTechnical difficulty\u003c\/h3\u003e\n\u003cp class=\"justify\" style=\"color:var(--gv3-ink-2);margin:0 0 14px\"\u003eTwo very different levels. Public access is effortless: the variant search needs nothing, and connecting an AI client to the MCP endpoint takes one line of configuration over Streamable HTTP, with no account, API key or OAuth flow. Laboratory access is contractual rather than technical: you create an account, choose an Individual or Laboratory profile, may be asked to evidence professional qualification, and must have an authorised representative accept the data processing agreement before any patient data is uploaded. Nothing is installed: the product is web-based and a conforming pseudonymised VCF is uploaded over TLS.\u003c\/p\u003e\n\u003ch3 style=\"font-size:15px;margin:14px 0 10px\"\u003eDeployment\u003c\/h3\u003e\n\u003cdiv class=\"flag-row\"\u003e\n\u003cspan class=\"flag\"\u003eWeb app\u003c\/span\u003e\u003cspan class=\"flag\"\u003eAPI\u003c\/span\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"setup-card\"\u003e\n\u003ch3 style=\"font-size:15px;margin-bottom:10px\"\u003eIntegrations\u003c\/h3\u003e\n\u003cdiv class=\"integrations\"\u003e\n\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e ChatGPT\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Claude\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Cursor\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Visual Studio Code\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Gemini CLI\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Perplexity\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Grok\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Windsurf\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Codex\u003c\/span\u003e\u003cspan class=\"integration\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M6.3 20.3a2.4 2.4 0 0 0 3.4 0L12 18l-6-6-2.3 2.3a2.4 2.4 0 0 0 0 3.4Z\"\u003e\u003c\/path\u003e\u003cpath d=\"m2 22 3-3\"\u003e\u003c\/path\u003e\u003cpath d=\"M7.5 13.5 10 11\"\u003e\u003c\/path\u003e\u003cpath d=\"M10.5 16.5 13 14\"\u003e\u003c\/path\u003e\u003cpath d=\"m18 3-4 4h6l-4 4\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Stripe\u003c\/span\u003e\n\u003c\/div\u003e\n\u003ch3 style=\"font-size:15px;margin:14px 0 10px\"\u003eSupported languages\u003c\/h3\u003e\n\u003cdiv class=\"flag-row\"\u003e\u003cspan class=\"flag\"\u003eEnglish\u003c\/span\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block soft\" id=\"company\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eCompany\u003c\/span\u003e\u003ch2\u003eBehind Folklore\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"company-grid\"\u003e\n\u003cdiv class=\"company-card\"\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eCompany name\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e\u003cb\u003eHelena Bioinformatics EOOD\u003c\/b\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eFounded\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e13\/08\/2026\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eCountry of origin\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e🇧🇬 Bulgaria\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eHeadquarters\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e14 Tsar Ivan Asen II Street, floor 1, apartment 1, 1142 Sofia, Bulgaria\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eUBO\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003eINFORMATION_NOT_FOUND\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eUBO country\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003eINFORMATION_NOT_FOUND\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eDomain registrar country\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e🇺🇸 United States\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"kv\"\u003e\n\u003cdiv class=\"k\"\u003eLegal contact\u003c\/div\u003e\n\u003cdiv class=\"v\"\u003e\u003ca href=\"mailto:legal@helena.bio\"\u003elegal@helena.bio\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"display:grid;gap:14px\"\u003e\u003cdiv class=\"company-card\"\u003e\n\u003ch3 style=\"font-size:15px;margin-bottom:10px\"\u003eSocial\u003c\/h3\u003e\n\u003cdiv class=\"social-row\"\u003e\n\u003ca class=\"social\" href=\"https:\/\/www.linkedin.com\/company\/helena-bioinformatics\/\" target=\"_blank\" rel=\"noopener\" aria-label=\"LinkedIn\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"18\" height=\"18\"\u003e\u003cpath d=\"M16 8a6 6 0 0 1 6 6v7h-4v-7a2 2 0 0 0-4 0v7h-4v-7a6 6 0 0 1 6-6z\"\u003e\u003c\/path\u003e\u003crect x=\"2\" y=\"9\" width=\"4\" height=\"12\"\u003e\u003c\/rect\u003e\u003ccircle cx=\"4\" cy=\"4\" r=\"2\"\u003e\u003c\/circle\u003e\u003c\/svg\u003e\u003c\/a\u003e\u003ca class=\"social\" href=\"https:\/\/www.youtube.com\/@helenabioinformatics\" target=\"_blank\" rel=\"noopener\" aria-label=\"YouTube\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"18\" height=\"18\"\u003e\u003cpath d=\"M22.54 6.42a2.78 2.78 0 0 0-1.94-2C18.88 4 12 4 12 4s-6.88 0-8.6.46a2.78 2.78 0 0 0-1.94 2A29 29 0 0 0 1 11.75a29 29 0 0 0 .46 5.33A2.78 2.78 0 0 0 3.4 19c1.72.46 8.6.46 8.6.46s6.88 0 8.6-.46a2.78 2.78 0 0 0 1.94-2 29 29 0 0 0 .46-5.25 29 29 0 0 0-.46-5.33z\"\u003e\u003c\/path\u003e\u003cpolygon points=\"9.75 15.02 15.5 11.75 9.75 8.48 9.75 15.02\"\u003e\u003c\/polygon\u003e\u003c\/svg\u003e\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block\" id=\"resources\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eOfficial links\u003c\/span\u003e\u003ch2\u003eResources\u003c\/h2\u003e\n\u003cp class=\"lead\"\u003eAll the official URLs gathered for verification and reference.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"res-grid\"\u003e\n\u003ca class=\"res\" href=\"https:\/\/folklore.helena.bio\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003ccircle cx=\"12\" cy=\"12\" r=\"10\"\u003e\u003c\/circle\u003e\u003cpath d=\"M12 2a14.5 14.5 0 0 0 0 20 14.5 14.5 0 0 0 0-20\"\u003e\u003c\/path\u003e\u003cpath d=\"M2 12h20\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003cdiv class=\"res-text\"\u003e\n\u003cdiv\u003eHomepage\u003c\/div\u003e\n\u003cdiv class=\"url\"\u003efolklore.helena.bio\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/a\u003e\u003ca class=\"res\" href=\"https:\/\/folklore.helena.bio\/how-it-works\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolygon points=\"12 2 2 7 12 12 22 7 12 2\"\u003e\u003c\/polygon\u003e\u003cpolyline points=\"2 17 12 22 22 17\"\u003e\u003c\/polyline\u003e\u003cpolyline points=\"2 12 12 17 22 12\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e\u003cdiv class=\"res-text\"\u003e\n\u003cdiv\u003eFeatures\u003c\/div\u003e\n\u003cdiv class=\"url\"\u003efolklore.helena.bio\/how-it-works\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/a\u003e\u003ca class=\"res\" href=\"https:\/\/folklore.helena.bio\/about\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003ccircle cx=\"12\" cy=\"12\" r=\"10\"\u003e\u003c\/circle\u003e\u003cline x1=\"12\" y1=\"16\" x2=\"12\" y2=\"12\"\u003e\u003c\/line\u003e\u003cline x1=\"12\" y1=\"8\" x2=\"12.01\" y2=\"8\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003cdiv class=\"res-text\"\u003e\n\u003cdiv\u003eAbout\u003c\/div\u003e\n\u003cdiv class=\"url\"\u003efolklore.helena.bio\/about\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/a\u003e\u003ca class=\"res\" href=\"https:\/\/www.helena.bio\/contact\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003crect x=\"2\" y=\"4\" width=\"20\" height=\"16\" rx=\"2\"\u003e\u003c\/rect\u003e\u003cpath d=\"m22 7-10 5L2 7\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003cdiv class=\"res-text\"\u003e\n\u003cdiv\u003eContact\u003c\/div\u003e\n\u003cdiv class=\"url\"\u003ewww.helena.bio\/contact\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/a\u003e\u003ca class=\"res\" href=\"https:\/\/folklore.helena.bio\/video\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolygon points=\"6 3 20 12 6 21 6 3\"\u003e\u003c\/polygon\u003e\u003c\/svg\u003e\u003cdiv class=\"res-text\"\u003e\n\u003cdiv\u003eDemo\u003c\/div\u003e\n\u003cdiv class=\"url\"\u003efolklore.helena.bio\/video\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/a\u003e\u003ca class=\"res\" href=\"https:\/\/www.helena.bio\/terms\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M14 2H6a2 2 0 0 0-2 2v16a2 2 0 0 0 2 2h12a2 2 0 0 0 2-2V8z\"\u003e\u003c\/path\u003e\u003cpolyline points=\"14 2 14 8 20 8\"\u003e\u003c\/polyline\u003e\u003cline x1=\"16\" y1=\"13\" x2=\"8\" y2=\"13\"\u003e\u003c\/line\u003e\u003cline x1=\"16\" y1=\"17\" x2=\"8\" y2=\"17\"\u003e\u003c\/line\u003e\u003cpolyline points=\"10 9 9 9 8 9\"\u003e\u003c\/polyline\u003e\u003c\/svg\u003e\u003cdiv class=\"res-text\"\u003e\n\u003cdiv\u003eTerms\u003c\/div\u003e\n\u003cdiv class=\"url\"\u003ewww.helena.bio\/terms\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/a\u003e\u003ca class=\"res\" href=\"https:\/\/www.helena.bio\/privacy\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M12 22s8-4 8-10V5l-8-3-8 3v7c0 6 8 10 8 10z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003cdiv class=\"res-text\"\u003e\n\u003cdiv\u003ePrivacy policy\u003c\/div\u003e\n\u003cdiv class=\"url\"\u003ewww.helena.bio\/privacy\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/a\u003e\u003ca class=\"res\" href=\"https:\/\/folklore.helena.bio\/docs\/folklore-connector\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpath d=\"M2 3h6a4 4 0 0 1 4 4v14a3 3 0 0 0-3-3H2z\"\u003e\u003c\/path\u003e\u003cpath d=\"M22 3h-6a4 4 0 0 0-4 4v14a3 3 0 0 1 3-3h7z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e\u003cdiv class=\"res-text\"\u003e\n\u003cdiv\u003eAPI documentation\u003c\/div\u003e\n\u003cdiv class=\"url\"\u003efolklore.helena.bio\/docs\/folklore-connector\u003c\/div\u003e\n\u003c\/div\u003e\u003c\/a\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block\" id=\"faq\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eFAQ\u003c\/span\u003e\u003ch2\u003eFrequently asked questions\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"faq\"\u003e\n\u003cdetails\u003e\u003csummary\u003eWhat file formats and genome builds does Folklore accept? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eSingle-sample VCF 4.1 or 4.2 files, plain text or bgzipped; multi-sample files must be split first, and FASTQ or BAM are not accepted. GRCh38 is the primary build. GRCh37 files are accepted and automatically lifted over with CrossMap, while hg18 and earlier builds are unsupported.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eDoes an AI model decide whether a variant is pathogenic? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eNo. The vendor states that classification is strictly rule-based and that no AI model determines pathogenicity. The AI assistant can explain why criteria fired and discuss the evidence, but it cannot change a classification. Only the reviewing geneticist can override an automated result.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eIs a Folklore result a diagnosis? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eNo. The vendor describes it as clinical decision support. Every automated classification, screening priority and generated interpretation must be independently reviewed and validated by a qualified clinical professional before it is used in patient care.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eWhere is patient data stored? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eOn EU infrastructure in Helsinki, Finland, on a dedicated server rather than a multi-tenant cloud. The vendor states that no genomic or personal data is transferred outside the European Economic Area, and that the variant processing pipeline has no outbound network access.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eWhat does Folklore cost? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eNo paid price is published. The terms state that version 1.0 supports a free plan without a payment card, and the public variant search and MCP endpoint are free with no account. Paid access is described to investors as per-case purchase, prepaid volumes or an annual commitment, and pricing enquiries go through the company contact address.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eIs there an API? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eYes. Folklore publishes a free, read-only MCP endpoint that requires no account, API key or OAuth flow, with four tools and five workflow prompts, a connector guide, an official MCP registry identity and an Apache-2.0 adapter on GitHub. It accepts public variant-level queries only, never patient or case data.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eHow many reference databases does Folklore use? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eThe vendor distinguishes two counts: 16 production classification and reference databases in the core enrichment stage, and 45 reference databases and curated sources in total across all modules. Smaller figures quoted for individual subsystems are not platform-wide totals.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eWhat is the regulatory status? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eThe company states plainly that the product is Research Use Only and not CE-marked. An IVDR conformity assessment submission is described as anticipated for the third quarter of 2027 or later, conditional on funding and organisational growth.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eWhich variant types are outside the scope? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eSomatic and tumour variants are not supported, and repeat expansions are neither detected nor interpreted. The structural and copy-number module interprets calls already present in the VCF and does not replace upstream structural-variant calling.\u003c\/div\u003e\u003c\/details\u003e\u003cdetails\u003e\u003csummary\u003eWho is behind Folklore? \u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2.5\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cline x1=\"12\" y1=\"5\" x2=\"12\" y2=\"19\"\u003e\u003c\/line\u003e\u003cline x1=\"5\" y1=\"12\" x2=\"19\" y2=\"12\"\u003e\u003c\/line\u003e\u003c\/svg\u003e\u003c\/summary\u003e\u003cdiv class=\"ans justify\"\u003eHelena Bioinformatics EOOD, registered at 14 Tsar Ivan Asen II Street in Sofia, Bulgaria. Folklore is one of four products alongside Undertone, Noodle and Evidence. The company describes itself as seed stage and founder-financed, without institutional investment.\u003c\/div\u003e\u003c\/details\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003csection class=\"block conclusion\" id=\"conclusion\"\u003e\u003cdiv class=\"head\"\u003e\n\u003cspan class=\"eyebrow\"\u003eConclusion\u003c\/span\u003e\u003ch2\u003eShould you pick Folklore?\u003c\/h2\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rich justify\" style=\"max-width:80ch\"\u003e\n\u003cp\u003eFolklore is one of the more transparent products a clinical genetics laboratory is likely to evaluate. The vendor publishes 131 canonical pages, a per-version changelog, an explicit limitations page and four validation cohorts with citable DOIs, and it goes as far as publishing reading rules that correct over-interpretation of its own figures. The engineering position is coherent: classification is rule-based, no model touches the class calculation, private genomic processing sits on dedicated hardware in Finland, and the analysis pipeline has no outbound network route.\u003c\/p\u003e\n\u003cp\u003eThe reservations are equally clear, and most of them come from the vendor's own documents. The product is Research Use Only and not CE-marked; an IVDR submission is a 2027 intention conditional on funding. Helena holds no certification of its own, and the ISO 27001 that appears in its impact assessment belongs to its hosting provider. The published agreement rate on the largest cohort is 67.0%. All three legal documents are labelled as candidates for legal review, and the documentation contradicts itself on whether the clinical assistant may call an external language model, and on the default retention period. The company is seed stage, founder-financed and currently seeking investment.\u003c\/p\u003e\n\u003cp\u003eThere is no published price, so any budgeting exercise starts with a sales conversation. The compensation is that the free public endpoint lets a laboratory judge classification quality on known variants before committing to anything at all. For a team that reads documentation closely and intends to keep a qualified specialist in the loop, that is an unusually honest starting point. For anyone needing a certified diagnostic device today, it is not the right tool.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"cta-row\"\u003e\n\u003ca class=\"btn btn-primary\" href=\"https:\/\/folklore.helena.bio\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"16\" height=\"16\"\u003e\u003cpath d=\"M15 3h6v6\"\u003e\u003c\/path\u003e\u003cpath d=\"M10 14 21 3\"\u003e\u003c\/path\u003e\u003cpath d=\"M18 13v6a2 2 0 0 1-2 2H5a2 2 0 0 1-2-2V8a2 2 0 0 1 2-2h6\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Visit Folklore\u003c\/a\u003e\u003ca class=\"btn btn-secondary\" href=\"https:\/\/folklore.helena.bio\/video\" target=\"_blank\" rel=\"noopener\"\u003e\u003csvg viewbox=\"0 0 24 24\" fill=\"none\" stroke=\"currentColor\" stroke-width=\"2\" stroke-linecap=\"round\" stroke-linejoin=\"round\" width=\"14\" height=\"14\"\u003e\u003cpolygon points=\"6 3 20 12 6 21 6 3\"\u003e\u003c\/polygon\u003e\u003c\/svg\u003e Watch the demo\u003c\/a\u003e\n\u003c\/div\u003e\u003c\/section\u003e\n\u003c\/div\u003e","brand":"Helena Bioinformatics EOOD","offers":[{"title":"Default Title","offer_id":58389620457803,"sku":null,"price":0.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1038\/0905\/7099\/files\/official-folklore-by-helena-bioinformatics-by-guidaio_f480dbda-b8fa-4a1e-8b3e-c846f7c877ca.png?v=1788730456","url":"https:\/\/guidaio.com\/products\/folklore-by-helena-bioinformatics","provider":"Guidaio","version":"1.0","type":"link"}